The IONA® Software automatically processes sequenced DNA fragments and clinical data such as prior risks like maternal age, into a self-contained or printable report. IONA® test results are exportable in common formats to enable local off-line further analysis and monitoring. Reports can be customised to meet the hospital or clinic's requirements and can be translated into local languages. The IONA® test report gives clear, easy to interpret results of high risk or low risk for each trisomy. High risk results should be confirmed with a follow-up diagnostic test. Risk scores can be combined with other markers (e.g. biochemical) to provide the most accurate probability assessment.
IONA® test results are reported as:
Low Risk: it is very unlikely the pregnancy is affected by trisomy 21, 18 or 13
High Risk: the pregnancy is at increased risk for trisomy 21, 18 or 13 and the result should be confirmed by a follow-up invasive procedure, such as an amniocentesis or CVS.
No Result: very occasionally there is insufficient placental DNA in the sample to obtain a result. Women may be asked back by the healthcare provider for a further blood sample.
Fetal sex determination
The IONA® test offers optional testing to determine the baby’s sex. A “sex determination failure” result may be reported if there is insufficient data to support the sex determination analysis. A failed result does not reflect on the quality of any other result generated by the IONA® test. Please note that the sex determining technique is not a screening test for rare sex chromosome conditions and is not currently available for multiple births except for identical (monochorionic) twin pregnancies. We therefore recommend that fetal sex determination is confirmed by ultrasound.
Fetal sex determination is only available for singleton and monochorionic twin pregnancies. It is only offered in regions where fetal sex determination is permitted.
A sample IONA® screening report is available for download here.